Design and Development of Polymer Based Diagnostic Tools for Bioluminescent Imaging Using Controlled Radical Polymerization Techniques

Design and Development of Polymer Based Diagnostic Tools for Bioluminescent Imaging Using Controlled Radical Polymerization Techniques

Dr. K. Rajendra Kumar, Senior Assistant Professor, Chemistry Division, School of Advanced Sciences is the Principal Investigator of the DST-SERB project, entitled, “Design and Development of Polymer Based Diagnostic Tools for Bioluminescent Imaging Using Controlled Radical Polymerization Techniques”.This project was for a period of 3 years (2013-2017) with a sanctioned amount of 39.22 lakhs. This work is basically focused on the use of small molecule and macromolecular luminescent products for imaging and sensing applications. Luminol, a widely used chemiluminescent molecule for chemo and biosensing. A symmetrical azo derivative of luminol (AzoLum) was synthesized and employed as a trimodal, selective and sensitive sensor for Hg2+ ions in water (Level of detection = 0.4 ppb). The three modes of mercury sensing include, change in cis-trans isomerization, fluorescence quenching and Chemiluminescence enhancement.

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